Protecting the liver: are hepatoprotectors effective?

In our country, hepatoprotectors and drugs “to improve cerebral circulation” and are poured in liters, because the desire of people to “protect”, “clean” and “restore” the liver, and also “clean” the blood vessels is ineradicable.
Let’s not talk about blood vessels today, let’s talk about the liver.
Its main function is to neutralize toxic substances, and this does not happen due to the accumulation of these toxins in the liver, but due to chemical reactions, when a harmful substance is first oxidized, reduced or hydrolyzed, and then some substance is added to these already changed molecules , thanks to which all this becomes harmless and excreted from the body. And there is no question of the toxins simply “settling in the liver”, there are no such mechanisms.
By the way, an excellent property of the liver is its ability to regenerate, that is, to grow back to normal size without losing function, even when only 25% of it remained.
In some cases, the liver can actually stop performing its function when hepatocytes (liver cells) are damaged for one reason or another.
Why is this happening?
In about 10% of cases, liver damage occurs due to drugs, herbal preparations, and dietary supplements.
Damage can also occur due to natural and household toxic substances, viruses (viral hepatitis), alcohol (alcoholic hepatitis, cirrhosis), tumors, fatty hepatosis, (hepatocytes accumulate excess fat, then inflammation begins in the liver, and then fibrosis, when normal tissue is gradually replaced by scar tissue, which can lead to cirrhosis of the liver – normal cells die, and scars form in their place), autoimmune diseases.
If liver damage occurs, of course, we must first of all eliminate the factor that caused this damage, otherwise nothing will change, and the cells will continue to be damaged. A simple example – if a person with alcoholic hepatitis continues to drink alcohol, then no drug in the world will help restore the liver.)
And if with fatty liver hepatosis you continue to eat whatever is horrible, do not play sports, do not change your lifestyle, then nothing will save your hepatocytes. Among the drugs, the most common drugs that cause liver damage and toxic hepatitis are paracetamol, antibiotics, including amoxicillin + clavulanate, dietary supplements and herbal preparations (according to statistics from different countries, dietary supplements and preparations based on herbs cause from 20 to 70% of episodes liver damage due to,
drugs, that is, sometimes more often than drugs). Among the non-drug causes, the most common are alcohol, viruses (primarily hepatitis B, C), and lifestyle.
Of course, changing your lifestyle is always difficult. Protect the liver in the right way – eat normally, do not exceed the permissible dose of alcohol (no more than one dose per day, and no more than $ once a week, one dose is 85 ml of spirits or 185 ml of wine), get vaccinated against hepatitis B, play sports , do not take herbal medications and dietary supplements that have not been tested, not standardized, do not take antibiotics for no reason, like other drugs without a doctor’s prescription, and doctors need to stop prescribing anything without a reason – this is what helps the liver normally
function. But this is all complicated. It’s much easier to come up with magic ways-
“Cleaning” the liver (how can it be cleaned if no toxins settle there, and if the liver starts to function poorly, this is due to cell damage and replacement of normal tissue?), Enemas and tyubazh, fasting (if you have been starving for two days, and , before and after that you continue to lead an unhealthy lifestyle, it will not affect the state of the liver in any way, do not even hope, but it creates the illusion that you are doing something, and this is bad, and, of course, the very same hepatoprotectors. supposedly protect the liver from harmful factors, creating a dangerous illusion that you can do whatever you want, drink any medicine, in any quantity, alcohol and eat junk food, and if you drink these drugs, then everything will be fine.
Is it so?
Some of these drugs are herbal, and the herbs themselves are often hepatotoxic. No one still knows the exact principles of how hepatoprotectors work, and even what they should do to protect the liver. To put
block for alcohol? Neutralize medications entering the body? Destroy
the fats we eat right on the way to the liver? Dissolve the already forming
scar tissue?
One of the famous hepatoprotectors proudly writes in the instructions that it contains phospholipids, which are incorporated into the damaged membranes of hepatocytes, and the cells are restored. It sounds beautiful, but in fact, such a mechanism is very difficult to implement, and there is no evidence that if we drink phospholipids as part of a capsule, they will certainly be incorporated into the membrane of the hepatocytes and the damaged ones.
Another popular ingredient is part of the licorice root, and there is also no evidence that licorice can restore hepatocytes. Manufacturers write on their websites that there is evidence of effectiveness and that there are many studies, but if you open these studies, it turns out that almost all of them did not show special results, there were small groups of patients, but, a statistically significant difference between the placebo group and the group receiving the drug was not. According to some reports, patients who
take hepatoprotectors, may end up falling into a dangerous delusion that they
and their livers are protected, as a result they will receive more traumatic
factors for the liver and, as a result, have a higher risk of damage. (Perhaps someday they will come up with drugs that can protect and restore the liver, of course, provided that you yourself do not damage it unnecessarily, but so far, alas, there are no such drugs.
And the main hepatoprotector is yourself. To do this, it is enough to do all the same boring
-Eat normal healthy food
-Take medicine. only about, but not from fear,
-Very careful about herbs and dietary supplements
-Minimize alcohol consumption
And enemas, tubazh, fasting and hepatoprotectors, as well as detox programs, are not included in this list.